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Hydrochlorothiazidea sulfonamidecan cause an idiosyncratic reactionresulting in acute transient myopia and acute angle-closure glaucomaSymptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiationUntreated acute angle-closure glaucoma can lead to permanent vision lossThe primary treatment is to discontinue hydrochlorothiazide as rapidly as possiblePrompt medical or surgical treatments may need to be considered if the intraocular pressure remains uncontrolledRisk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy.

Hypokalemia may develop with thiazide therapyespecially with brisk diuresiswhen severe cirrhosis is presentor during concomitant use of corticosteroidsACTHamphotericin B or after prolonged thiazide therapyHoweverhypokalemia of this type is usually prevented by the triamterene component of MAXZIDEtriamterene and hydrochlorothiazide

Keep out of reach of childrenIn case of overdoseget medical help or contact a Poison Control Center immediately.

Triamterene may cause side effectsTell your doctor if any of these symptoms are severe or do not go away:

Take this medication by mouth as directed by your doctorusually once or twice a day after a mealIf you take this drug too close to bedtimeyou may need to wake up to urinateIt is best to take this medication at least 4 hours before your bedtime.

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hydrochlorothiazide, hctz; triamterene major in general, antipsychotics like haloperidol should be used cautiously with antihypertensive agents due to the possibility of additive hypotension.

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